Education
Doctor of Philosophy (Nutrition), Washington State University: 1984
Master of Science (Chemistry), Washington State University: 1975
Bachelor of Arts (Biology), Southern Connecticut State University: 1971

Research
Our research is focused on determining mechanisms involved in avian skeletal muscle development. This research utilizes a number of cell culture and biochemical techniques. We are examining the effects of growth factors on avian skeletal muscle development using myogenic satellite cells in culture.  More specifically, ongoing projects include examination of heterogeneity in the population of satellite cells with respect to growth factor response. Another project is focused on characterization of satellite cells from a genetic line with muscular weakness and abnormal extracellular matrix chemistry.   Studies are also underway to examine satellite cells from an animal model of muscular dystrophy.

Teaching
Animal Growth and Development, AS 750
Metabolism, AS 640

Selected Organizations/Appointments
American Society of Animal Science
Muscle Research Committee (NC-1131)
American Society for Nutritional Sciences
American Association for the Advancement of Science
Gamma Sigma Delta
Sigma Xi

Recent Publications

Mozdziak, P.E., D.C. McFarland, and E. Schultz. 2000. Telomeric Profiles and Telomerase Activity in Turkey Satellite Cell Clones with Different In Vitro Growth Characteristics. Biochimica et Biophysica Acta 1492:362-368.

Shappell, N.W., V.J. Feil, D.J. Smith, G.L. Larsen and D.C. McFarland.  2000. Response of C₂C₁₂ Mouse and Turkey Skeletal Muscle Cells to the beta-Adrenergic Agonist Ractopamine.   Journal of Animal Science 78(3): 699-708.

Velleman, Sandra G. and Douglas C. McFarland. 2000  Influence of Fibroblast Growth Factor, Insulin-Like Growth Factor I, and Transforming Growth Factor Beta on Satellite Cell Type I Collagen Expression and Localization During Differentiation.  Cytobios  100:101-110.

Blanton, Jr., J.R., C.A. Bidwell, D.A. Sanders, C.M. Sharkey, D.C. McFarland, D.E. Gerrard and A.L. Grant. 2000.  Plasmid Transfection and Retroviral Transduction of Porcine Muscle Cells for Cell-Mediated Gene Transfer.  Journal of Animal Science.  78:909-918.

McFarland, Douglas C. 2000. Preparation of Pure Cell Cultures by Cloning.  Methods in Cell Science 22:63-66.

38.     Velleman, Sandra G., Xiaosong Liu, Karl E. Nestor, and Douglas C. McFarland. 2000.  Heterogeneity in Growth and Differentiation Characteristics in Male and Female Satellite Cells Isolated from Turkey Lines with Different Growth Rates.  Comparative Biochemistry and Physiology Part A 125:503-509.

McFarland, Douglas C., Yadhu N. Singh, Angela D. Johnson, Jane E. Pesall, Kysa K. Gilkerson, and Londa S. Vander Wal.  2000. Isolation and Characterization of Myogenic Satellite Cells from the Muscular Dystrophic Hamster.  Tissue and Cell 32(3):257-265.

Velleman, Sandra G., Cynthia S. Coy, Loriann Gannon, MacDonald Wick, and Douglas C. McFarland. 2000. Beta-1 Integrin Expression During Normal and Low Score Normal Avian Myogenesis.  Poultry Science 79:1179-1182.

Pesall, J.E., D.C. McFarland, J.P. McMurtry, J.A. Clapper, G.L. Francis, and K.K. Gilkerson. 2001. The Effect of Insulin-like Growth Factor Analogs on Turkey Satellite Cell and Embryonic Myoblast Proliferation.  Poultry Science 80:944-948.

Kocamis, H., D. C. McFarland, and J. Killefer.  2001.  Temporal Expression of Growth Factor Genes during Myogenesis of Satellite Cells Derived from the Biceps Femoris and Pectoralis Major Muscles of the Chicken. Journal of Cellular Physiology 186(1): 146-153.

Guan, Xiangming, Brianna N. Hoffman, Douglas C. McFarland, Kysa K. Gilkerson, Chandradhar Dwivedi, Angela K. Erickson, Scott Bebensee, and Jill Pellegrini. 2002. Glutathione and Mercapturic Acid Conjugates of Sulofenur and Their Activity Against a Human Colon Cancer Cell Line.  Drug Metabolism and Disposition 30:331-335.

Zeng, Caiyun, Jane E. Pesall, Kysa K. Gilkerson, and Douglas C. McFarland. 2002. The Effect of Hepatocyte Growth Factor (HGF) on Turkey Satellite Cell Proliferation and Differentiation. Poultry Science 81:1191-1198.

56.        Wick, Macdonald, Sandra G. Velleman, Cynthia S. Coy, Douglas C. McFarland, and Charles I. Pretzman.  2003. Myosin Heavy Chain Isoform Expression is Altered During In Vitro Myogenesis in Low Score Normal Chickens.  Comparative Biochemistry and Physiology 136(2):401-408. 

57.        Liu, Xiaosong, Karl E. Nestor, Douglas C. McFarland, and Sandra G. Velleman. 2002. Developmental Expression of Skeletal Muscle Heparan Sulfate Proteoglycans in Turkey Lines with Different Growth Rates. Poultry Science 81:1621-1628. 

58.        McFarland, Douglas C., Xiaosong Liu, Sandra G. Velleman, Caiyun Zeng, Cynthia S. Coy, and Jane E. Pesall. 2003. Variation in Fibroblast Growth Factor and Heparan Sulfate Proteoglycan Production in Satellite Cell Populations. Comparative Biochemistry and Physiology Part C 134:341-351. 

59.        Liu, X., D. C. McFarland, K. E. Nestor, and S. G. Velleman. 2003. Expression of Fibroblast Growth Factor 2 and its Receptor During Skeletal Muscle Development in Turkeys with Different Growth Rates. Domestic Animal Endocrinology 25(2):215-219. 

60.        Liu, Xiaosong, Douglas C. McFarland, Karl E. Nestor, and Sandra G. Velleman. 2004. Developmental regulated expression of syndecan-1 and glypican in pectoralis major muscle with different growth rates. Dev. Growth Differ.  46:37-51. 

61.        Velleman, Sandra G. and Douglas C. McFarland. 2004. Beta1 Integrin Mediation of Myogenic Differentiation: Implications for Satellite Cell Differentiation. Poultry Science 83:245-252. 

62.       Velleman, Sandra G., Xiaosong Liu, Cynthia S. Coy, and Douglas C. McFarland. 2004. Effects of Syndecan-1 and Glypican on Muscle Cell Proliferation and Differentiation: Implications for Possible Functions During Myogenesis.  Poultry Science 83:1020-1027. 

67.     Edelman, P. D., D. C. McFarland, V. A. Mironov, and J. G. Matheny. 2005. In vitro Cultured Meat Production: Commentary. Tissue Engineering 11(5/6): 659-662. 

68.     Liu, C., D. C. McFarland, S. G. Velleman. 2005. Effect of Selection on MyoD and Myogenin Expression in Turkeys with Different Growth Rates. Poultry Science 84:376-384.69.    

Velleman, S. G., C. Liu, C. S. Coy, and D. C. McFarland. 2006. Effects of Glypican-1 on Turkey Skeletal Muscle Cell Proliferation, Differentiation, and Fibroblast Growth Factor 2 Responsiveness. Development, Growth and Differentiation. Development Growth & Differentiation 48:271-276.

Liu, Caini, Douglas C. McFarland, Karl E. Nestor, and Sandra G. Velleman. 2006. Differential Expression of Membrane-associated Heparan Sulfate Proteoglycans in the skeletal muscle of turkeys with different growth rates. Poultry Science 85:422-428.

Li, X., D. C. McFarland, and S. G. Velleman. 2006. Effect of Transforming Growth Factor Beta on Decorin and Beta 1 Integrin Expression during Muscle Development in Chickens. Poultry Science 85:326-332.

McFarland, Douglas C., Sandra G. Velleman, Jane E. Pesall, and Caini Liu. 2006. Effect of Myostatin on Turkey Myogenic Satellite Cells and Embryonic Myoblasts. Comparative Biochemistry and Physiology 144(4): 501-508.

Velleman, S. G., X. Li, C. S. Coy, C. Liu, and D. C. McFarland. Association of membrane-associated heparan sulfate proteoglycan expression and fibroblast growth factor-2 in turkey muscle satellite cells. (Submitted)

McFarland, Douglas C., Sandra G. Velleman, Jane E. Pesall, and Caini Liu. The role of myostatin in chicken (Gallus domesticus) myogenic satellite cell proliferation and differentiation.  General and Comparative Endocrinology (submitted)

Book Chapter

McFarland, Douglas C. 2003. Nutrition and Growth, In: Biology of Growth of Domestic Animals, Iowa State University Press, pp. 249-262.

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